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Scientists identify key building blocks for RNA in a cloud in the Milky Way

Discovery: Some of the fundamental building blocks of life, known as nitrile, have been identified by scientists at the heart of our Milky Way galaxy.  They were detected in a molecular cloud of gas and dust (similar to the one pictured) by an international team of researchers.
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Some of the fundamental building blocks of life, known as nitriles, have been identified by scientists at the heart of our Milky Way galaxy.

They were detected in a molecular cloud of gas and dust by an international team of researchers using two telescopes. Spain.

Nitriles are important building blocks for RNA, a DNA-like nucleic acid found in all living cells.

Experts said their discovery suggests that nitriles are one of the most abundant chemical families in the universe and lends support to the ‘RNA World’ theory of the origin of life.

This suggests that life on Earth originally relied solely on RNA, and DNA and protein enzymes evolved later.

RNA can perform both functions: storing and transcribing information, such as DNA, and catalyzing reactions, such as enzymes.

According to the ‘RNA World’ theory, nitriles and other building blocks for life need not all have originated on Earth itself.

Discovery: Some of the fundamental building blocks of life, known as nitrile, have been identified by scientists at the heart of our Milky Way galaxy.  They were detected in a molecular cloud of gas and dust (similar to the one pictured) by an international team of researchers.

Discovery: Some of the fundamental building blocks of life, known as nitrile, have been identified by scientists at the heart of our Milky Way galaxy. They were detected in a molecular cloud of gas and dust (similar to the one pictured) by an international team of researchers.

Experts said their discovery suggests that nitriles are one of the most abundant chemical families in the universe and lends support to the 'RNA World' theory of the origin of life.  This suggests that nitriles may have originated in space, and that they may have entered young Earth in meteorites and comets.

Experts said their discovery suggests that nitriles are one of the most abundant chemical families in the universe and lends support to the ‘RNA World’ theory of the origin of life. This suggests that nitriles may have originated in space and “hitchhiked” to young Earth in meteorites and comets (stock image)

LIFE ON THE WORLD MAY HAVE STARTED THANKS TO A CHANGED VERSION OF MODERN-DAY RNA

Scientists believe that life on Earth may have started thanks to a modified version of today’s DNA sister molecule.

DNA is the backbone of life and nearly our entire planet depends on it, but experts say that on primeval Earth, a primitive version of its lesser-known sister RNA was the focus of evolution.

RNA is structurally similar to DNA, but one of the four essential parts, thymine, is substituted for uracil.

This changes the shape and structure of the molecule, and researchers have long believed this chemical was vital for the development of Earth’s first life forms.

An accidental discovery published in December 2018 by Harvard academics found that a slightly different version of RNA could be the main ingredient that allowed life on Earth to blossom.

Scientists claim that instead of guanine, a chemical called inosine may be present, allowing life to flourish.

This tiny change in bases, known as a nucleotide, could provide the first known proof of the ‘RNA World Hypothesis’ – a theory that claims RNA was an integral part of primitive life forms, they say.

They may also have arisen in space and ‘hitchhiked’ to young Earth amidst meteorites and comets during the ‘Late Heavy Bombardment’ 4.1 to 3.8 billion years ago.

As support, nitriles and other precursor molecules for nucleotides, lipids, and amino acids have been found in recent comets and meteorites.

The question is, where could these molecules have come from in space?

Prime candidates are molecular clouds, which are dense and cold regions of the interstellar medium suitable for the formation of complex molecules.

For example, molecular cloud G+0.693-0.027 has a temperature of about 100 K, is about three light-years across, and has a mass of about a thousand times our Sun.

There is currently no evidence of stars forming inside G+0.693-0.027, but scientists suspect it may become a stellar nursery in the future.

The team of experts identified a number of nitriles, including cyanoallene, propargyl cyanide, cyanopropin, and possibly cyanoformaldehyde and glycolnitrile; none of these had been in the cloud before and were known as G+0.693-0.027.

Lead study author Dr Víctor M. Rivilla, a researcher at Spain’s National Research Council’s Center for Astrobiology, said: “We show here that the chemistry that takes place in the interstellar medium can efficiently form the multiple nitriles that are so important. Molecular precursors of the “RNA World” scenario.

The chemical content of G+0.693-0.027 is similar to that of other star forming regions in our galaxy, as well as solar system objects such as comets.

‘This means that his work could give us important insights into the chemicals found in the nebula that gave rise to our planetary system.’

Researchers used the 100ft (30m) wide IRAM telescope Granada and the 130ft (40m) Yebes telescope in Guadalajara.

The team of experts detected a number of nitriles, including cyanoallene, propargyl cyanide and cyanopropylene, although they were not yet found in G+0.693-0.027 but were reported in the TMC-1 dark cloud in the constellation Taurus in 2019. and Auriga, a molecular cloud with conditions very different from G+0.693-0.027.

The scientists also found possible evidence of cyanoformaldehyde and glycolonitrile.

Cyanoformaldehyde was first detected in the molecular clouds of TMC-1 and Sgr B2 in the constellation Sagittarius and glycolonitrile in the Sun-like protostar IRAS16293-2422 B in the constellation Ophiuchus.

Two types of chemical building blocks – or nucleobases – are required for DNA and RNA to form.

Two types of chemical building blocks – or nucleobases – are required for DNA and RNA to form.

Co-study author Dr Miguel A Requena-Torres, a lecturer at Towson University in Maryland, said: ‘Thanks to our observations over the last few years, including current results, we now know that nitriles are one of the most abundant chemical families in the world. Universe.

“We found them in molecular clouds at the center of our galaxy, protostars of different masses, meteorites and comets, as well as in the atmosphere of Saturn’s largest moon, Titan.”

Author Dr Izaskun Jiménez-Serra, also a researcher at the Spanish National Research Council Center for Astrobiology, said: “So far we have identified several simple precursors of ribonucleotides, which are the building blocks of RNA.

But there are still important missing molecules that are difficult to detect.

For example, we know that the origin of life on Earth probably also required other molecules, such as lipids, that were responsible for the formation of the first cells.

“Therefore, we should also focus on understanding how lipids can form from simpler precursors found in the interstellar medium.”

The study was published in the journal limits.

DNA AND RNA EXPLAIN: MOLECULES CONTAINING GENETIC INFORMATION FOR LIFE

DNA – deoxyribonucleic acid – is known as the molecule found in the nucleus of all our cells that contains genetic information.

It is in the form of a double helix and consists of small segments called nucleotides.

Each nucleotide contains a nucleobase, a sugar, and a phosphate group.

The sugar component in this particular molecule is called deoxyribose and forms the D in DNA.

It is a cyclic carbon-based chemical with five carbon atoms arranged in a pentagon.

The second carbon atom has a single hydrogen atom bonded to deoxyribose.

This can also have an additional oxygen.

In this case, the oxygenated chemical then forms what is simply known as ribose – the R in RNA.

this deoxy prefix literally means without oxygen.

Shape of RNA and DNA

RIbose can do almost everything that deoxyribose can, and it also encodes the genetic information in some cells and organisms.

When oxygen is present, it drastically changes how chemicals bind and sit next to other molecules.

When oxygen is present – in RNA – it can take various forms.

In the absence of oxygen at this particular location – in DNA – the molecule forms as the iconic double helix.

Uses of RNA

DNA is often broken down into RNA and read by cells to translate and copy the genetic code to make proteins and other molecules essential for life.

RNA uses three of the same base pairs as DNA: Cytosine, Guanine, Adenine.

The other base pair Thymine is replaced in RNA for Uracil.

RNA is also found in simpler organisms such as bacteria.

It is a virus that usually also contains all RNA forms of Hepatitis, influenza, and HIV.

mitochondrial RNA

All animal cells use DNA, with one notable exception: mitochondria.

Mitochondria are the powerhouses of the cell and convert glucose to pyruvate and then to Adenosine triphosphate (ATP) via the Krebs cycle.

All of this process is done in this single organelle in cells and ATP is the universal form of energy and is used in every aerobic organism.

Mitochondria have a small sequence of RNA that is unique in the animal kingdom.

It is transmitted only from the mother (the father’s life in the sperm is only resolved at fertilization) and allows people to trace the maternal lineage over time.

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